Shrooms and Other Medication or Drugs

Mixing psilocybin with other drugs can increase or decrease the intensity of the experience and may have unintended consequences. The effects may be adverse as some medicines may not mix well with your mushrooms (see our webinar on drug-drug interactions). In addition, psilocybin works on our serotonin system, so it works on the same receptors as antidepressants, which can severely blunt the effects of the mushrooms. Talk to your doctor about any medications you’re taking and how to safely titrate off of them in order to have a meaningful and safe experience. 

Ideally, alcohol should be abstained from for a minimum of a week prior to taking your magic mushrooms and you should stay off it for a week or so afterwards in order to optimize the beginning of the integration process. Drinking alcohol while on shrooms is not advised. It may lead to making poor choices that put yourself and others at risk for accidents or other uncomfortable situations.  

Combining MDMA with psilocybin mushrooms, known as “hippie-flipping”, may increase known side effects of both substances and though not common, could potentially cause serious complications from too much serotonin released in the brain (called serotonin syndrome). Abstaining from MDMA for at least a month prior to psilocybin use will ensure the full desired effects of psilocybin are reached. 

Your magic mushroom experience should be approached seriously. By being respectful to the medicine, having intentions, paying attention to set and setting, and not mixing drugs or alcohol, one greatly reduces the risk of adverse effects.